Simulations Plus
Drug discovery software
Life sciences software
- Features
- Ease of use
- Ease of management
- Quality of support
- Affordability
- Market presence
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What is Simulations Plus
Simulations Plus is a suite of modeling and simulation software used to support drug discovery and development decisions, with a focus on pharmacokinetics/pharmacodynamics (PK/PD), physiologically based pharmacokinetic (PBPK) modeling, and ADMET prediction. It is used by pharmacometricians, DMPK scientists, and clinical pharmacology teams to predict exposure, optimize dosing strategies, and assess formulation and drug–drug interaction risk. The product set is oriented toward mechanistic and semi-mechanistic simulation workflows rather than molecular docking or chemistry-first virtual screening.
Strong PBPK/PKPD focus
The platform is centered on PBPK and PK/PD modeling workflows that support translation from preclinical to clinical scenarios. It is commonly applied to simulate concentration–time profiles, evaluate dosing regimens, and explore covariates such as organ impairment or population differences. This emphasis differentiates it from tools in the space that primarily focus on structure-based design or compound registration.
ADMET and DDI assessment
Simulations Plus products include capabilities used for absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction and for evaluating drug–drug interaction (DDI) risk. These functions support early screening and later-stage clinical pharmacology questions, such as enzyme/transporter involvement and exposure changes under co-medication scenarios. The combination of simulation and ADMET-oriented prediction supports end-to-end decision support across discovery and development.
Regulatory-facing modeling workflows
PBPK and clinical pharmacology modeling outputs are often used to inform study design and support documentation for regulatory interactions. The software’s workflow orientation aligns with common deliverables such as scenario analyses, sensitivity analyses, and justification of dosing recommendations. This makes it a fit for organizations that need traceable modeling assumptions and reproducible simulation runs.
Not a docking-first platform
The core value is pharmacokinetics and mechanistic simulation rather than structure-based molecular modeling. Teams primarily focused on docking, scoring, and 3D ligand–protein design will typically need separate tools for those tasks. As a result, it may not replace chemistry-centric discovery platforms in the reference space.
Model building requires expertise
PBPK/PKPD modeling depends on correct parameterization, biological assumptions, and appropriate data inputs. Organizations without experienced pharmacometric or DMPK staff may face a learning curve and risk misinterpretation of results. Effective use often requires internal standards for model qualification and documentation.
Data integration can be nontrivial
Simulation quality depends on integrating assay, in vivo, and clinical data from multiple systems (e.g., LIMS/ELN, compound registries, and bioanalytical datasets). Connecting these sources and maintaining consistent metadata can require additional tooling or custom processes. This can add overhead compared with platforms that include built-in data management as a primary function.
Plan & Pricing
Pricing model: License-based / Enterprise (pricing not published on site; contact sales for quotes)
Publicly listed costs (official site):
- GastroPlus® Advanced Workshop (virtual): Commercial: $2,000; Concierge: $1,500; Academia: $1,000; Government/Non-Profit/Regulatory: $1,000. (training/event pricing).
- On-demand course bundles and workshops (examples): ranges shown on site, e.g., $25–$325 depending on course/bundle (Introductory and on‑demand course listings for GastroPlus, DDDPlus, RENAsym, etc.).
What is NOT publicly listed on the official site:
- Individual product license prices (GastroPlus®, ADMET Predictor®, MonolixSuite™, DILIsym®, Thales QSP, Pro‑ficiency ALI, etc.) are not published. The site repeatedly directs visitors to "Sign-up for a free evaluation", "Schedule a demo", or "Contact us" to receive quotes or trial access. Examples: product pages, product brochures, and plug‑and‑play/module pages describe features and bundles but do not list license fees or subscription tiers.
Other vendor-offered pricing-related items (official site):
- Consult + Coach / NAMVantage consulting packages: include free 3‑month licenses as part of the consulting bundle (price for the consulting package not published).
- DILIsym: the site states companies may request a free trial version and that membership/consortium fees exist for the DILI‑sim Initiative, but membership/commercial license fees are not published.
- Academic licensing: academic/teaching license options are documented (eligibility and that a license fee is required), but no public price points are shown.
Notes & next steps (official-site sources):
- For exact licensing costs, volume/seat pricing, and purchase terms, the official site instructs prospective customers to contact sales (info@simulations-plus.com), request a free evaluation, or schedule a demo.
Seller details
Simulations Plus, Inc.
Lancaster, California, USA
1996
Public
https://www.simulations-plus.com/
https://x.com/simulationsplus
https://www.linkedin.com/company/simulations-plus/
